Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p210 | (1) | WCRB2014

Proteomic analysis of human testicular interstitial fluid reflects disordered spermatogenesis in Klinefelter’s syndrome

McLachlan Robert I , Stephens Andrew N , Rainczuk Adam , Foo Caroline , Condina Mark R , Ishikawa Tomomoto , Weidner Wolfgang , Stanton Peter G

Introduction: Primary spermatogenic failure is the commonest cause of male infertility. Changes in Sertoli and germ cell function may be reflected in the testicular interstitial fluid (TIF) proteome and its analysis may provide insights into the pathophysiology. Microdissection testicular sperm extraction (microTESE) provides sperm for ICSI in ~50% of non-obstructive azoospermia (NOA) cases. As the first step in constructing a diagnostic approach for broader application in NOA...